Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

α-Synuclein (AS) is an intrinsically disordered protein highly expressed in dopaminergic neurons. Its amyloid aggregates are the major component of Lewy bodies, a hallmark of Parkinson's disease (PD). AS is particularly exposed to oxidation of its methionine residues, both in vivo and in vitro....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ponzini, Erika, De Palma, Antonella, Cerboni, Lucilla, Natalello, Antonino, Rossi, Rossana, Moons, Rani, Konijnenberg, Albert, Narkiewicz, Joanna, Legname, Giuseppe, Sobott, Frank, Mauri, PierLuigi, Santambrogio, Carlo, Grandori, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462524/
https://ncbi.nlm.nih.gov/pubmed/30755483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001907
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