Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large conformational space. Certain conformations lead to aggregation prone and non-aggregation prone intermediates, but identifying these within the dynamic ensemble of monomeric conformations is difficult. Herein,...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Stephens, Amberley D., Zacharopoulou, Maria, Moons, Rani, Fusco, Giuliana, Seetaloo, Neeleema, Chiki, Anass, Woodhams, Philippa J., Mela, Ioanna, Lashuel, Hilal A., Phillips, Jonathan J., De Simone, Alfonso, Sobott, Frank, Schierle, Gabriele S. Kaminski
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272411/
https://ncbi.nlm.nih.gov/pubmed/32499486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16564-3
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