Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in living cells. Here, we use deep mutational scanning...

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Published in:ACS Chem Biol
Main Authors: Newberry, Robert W., Arhar, Taylor, Costello, Jean, Hartoularos, George C., Maxwell, Alison M., Naing, Zun Zar Chi, Pittman, Maureen, Reddy, Nishith R., Schwarz, Daniel M. C., Wassarman, Douglas R., Wu, Taia S., Barrero, Daniel, Caggiano, Christa, Catching, Adam, Cavazos, Taylor B., Estes, Laurel S., Faust, Bryan, Fink, Elissa A., Goldman, Miriam A., Gomez, Yessica K., Grace Gordon, M., Gunsalus, Laura M., Hoppe, Nick, Jaime-Garza, Maru, Johnson, Matthew C., Jones, Matthew G., Kung, Andrew F., Lopez, Kyle E., Lumpe, Jared, Martyn, Calla, McCarthy, Elizabeth E., Miller-Vedam, Lakshmi E., Navarro, Erik J., Palar, Aji, Pellegrino, Jenna, Saylor, Wren, Stephens, Christina A., Strickland, Jack, Torosyan, Hayarpi, Wankowicz, Stephanie A., Wong, Daniel R., Wong, Garrett, Redding, Sy, Chow, Eric D., DeGrado, William F., Kampmann, Martin
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442712/
https://ncbi.nlm.nih.gov/pubmed/32786289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00339
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