Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in living cells. Here, we use deep mutational scanning...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Biol
Egile Nagusiak: Newberry, Robert W., Arhar, Taylor, Costello, Jean, Hartoularos, George C., Maxwell, Alison M., Naing, Zun Zar Chi, Pittman, Maureen, Reddy, Nishith R., Schwarz, Daniel M. C., Wassarman, Douglas R., Wu, Taia S., Barrero, Daniel, Caggiano, Christa, Catching, Adam, Cavazos, Taylor B., Estes, Laurel S., Faust, Bryan, Fink, Elissa A., Goldman, Miriam A., Gomez, Yessica K., Grace Gordon, M., Gunsalus, Laura M., Hoppe, Nick, Jaime-Garza, Maru, Johnson, Matthew C., Jones, Matthew G., Kung, Andrew F., Lopez, Kyle E., Lumpe, Jared, Martyn, Calla, McCarthy, Elizabeth E., Miller-Vedam, Lakshmi E., Navarro, Erik J., Palar, Aji, Pellegrino, Jenna, Saylor, Wren, Stephens, Christina A., Strickland, Jack, Torosyan, Hayarpi, Wankowicz, Stephanie A., Wong, Daniel R., Wong, Garrett, Redding, Sy, Chow, Eric D., DeGrado, William F., Kampmann, Martin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442712/
https://ncbi.nlm.nih.gov/pubmed/32786289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00339
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