Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in living cells. Here, we use deep mutational scanning...

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Publicat a:ACS Chem Biol
Autors principals: Newberry, Robert W., Arhar, Taylor, Costello, Jean, Hartoularos, George C., Maxwell, Alison M., Naing, Zun Zar Chi, Pittman, Maureen, Reddy, Nishith R., Schwarz, Daniel M. C., Wassarman, Douglas R., Wu, Taia S., Barrero, Daniel, Caggiano, Christa, Catching, Adam, Cavazos, Taylor B., Estes, Laurel S., Faust, Bryan, Fink, Elissa A., Goldman, Miriam A., Gomez, Yessica K., Grace Gordon, M., Gunsalus, Laura M., Hoppe, Nick, Jaime-Garza, Maru, Johnson, Matthew C., Jones, Matthew G., Kung, Andrew F., Lopez, Kyle E., Lumpe, Jared, Martyn, Calla, McCarthy, Elizabeth E., Miller-Vedam, Lakshmi E., Navarro, Erik J., Palar, Aji, Pellegrino, Jenna, Saylor, Wren, Stephens, Christina A., Strickland, Jack, Torosyan, Hayarpi, Wankowicz, Stephanie A., Wong, Daniel R., Wong, Garrett, Redding, Sy, Chow, Eric D., DeGrado, William F., Kampmann, Martin
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442712/
https://ncbi.nlm.nih.gov/pubmed/32786289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00339
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