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Identification of Novel Smoothened Ligands Using Structure-Based Docking
The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and medulloblastoma, and Smoothened inhibitors are now av...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4973902/ https://ncbi.nlm.nih.gov/pubmed/27490099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160365 |
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