Identification of Novel Smoothened Ligands Using Structure-Based Docking

The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and medulloblastoma, and Smoothened inhibitors are now av...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Lacroix, Celine, Fish, Inbar, Torosyan, Hayarpi, Parathaman, Pranavan, Irwin, John J., Shoichet, Brian K., Angers, Stephane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973902/
https://ncbi.nlm.nih.gov/pubmed/27490099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160365
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