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Protein Stability Effects in Aggregate-Based Enzyme Inhibition
Small-molecule aggregates are a leading cause of artifacts in early drug discovery, but little is known about their interactions with proteins, nor why some proteins are more susceptible to inhibition than others. A possible reason for this apparent selectivity is that aggregation-based inhibition,...
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| Publicado no: | J Med Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7156261/ https://ncbi.nlm.nih.gov/pubmed/31589047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01019 |
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