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Stable Colloidal Drug Aggregates Catch and Release Active Enzymes

Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the co-aggregation of seven molecules chosen because they had been previously intensely stu...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: McLaughlin, Christopher K., Duan, Da, Ganesh, Ahil N., Torosyan, Hayarpi, Shoichet, Brian K., Shoichet, Molly S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082698/
https://ncbi.nlm.nih.gov/pubmed/26741163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00806
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