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Stable Colloidal Drug Aggregates Catch and Release Active Enzymes

Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the co-aggregation of seven molecules chosen because they had been previously intensely stu...

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Publicat a:ACS Chem Biol
Autors principals: McLaughlin, Christopher K., Duan, Da, Ganesh, Ahil N., Torosyan, Hayarpi, Shoichet, Brian K., Shoichet, Molly S.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082698/
https://ncbi.nlm.nih.gov/pubmed/26741163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00806
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