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Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding
[Image: see text] One of the leading sources of false positives in early drug discovery is the formation of organic small molecule aggregates, which inhibit enzymes nonspecifically at micromolar concentrations in aqueous solution. The molecular basis for this widespread problem remains hazy. To inve...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical Society
2009
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664636/ https://ncbi.nlm.nih.gov/pubmed/19281222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801605r |
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