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A Detergent-Based Assay for the Detection of Promiscuous Inhibitors
At micromolar concentrations, many small molecules self-associate into colloidal aggregates that non-specifically inhibit enzymes and other proteins. Here we describe a protocol for identifying aggregate-based inhibitors and distinguishing them from small molecules that inhibit via specific mechanis...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1544377/ https://ncbi.nlm.nih.gov/pubmed/17191086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2006.77 |
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