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Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors
Many false positives in early drug discovery owe to nonspecific inhibition by colloid-like aggregates of organic molecules. Despite their prevalence, little is known about aggregate concentration, structure, or dynamic equilibrium; the binding mechanism, stoichiometry with, and affinity for enzymes...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2627561/ https://ncbi.nlm.nih.gov/pubmed/18588298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja802977h |
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