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Synergy and Antagonism of Promiscuous Inhibition in Multiple-Compound Mixtures
Screening in mixtures is a common approach for increasing the efficiency of high-throughput screening. Here we investigate how the “compound load” of mixtures influences promiscuous aggregate-based inhibition. We screened 764 molecules individually and in mixtures of 10 at 5 μM each, comparing the o...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1540993/ https://ncbi.nlm.nih.gov/pubmed/16570910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060029z |
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