Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-Derived Neurons

The induced pluripotent stem (iPS) cell field promises a new era for in vitro disease modeling. However, identifying innate cellular pathologies, particularly for age-related neurodegenerative diseases, has been challenging. Here, we exploited mutation correction of iPS cells and conserved proteotox...

Full description

Saved in:
Bibliographic Details
Main Authors: Chung, Chee Yeun, Khurana, Vikram, Auluck, Pavan K., Tardiff, Daniel F., Mazzulli, Joseph R., Soldner, Frank, Baru, Valeriya, Lou, Yali, Freyzon, Yelena, Cho, Sukhee, Mungenast, Alison E., Muffat, Julien, Mitalipova, Maisam, Pluth, Michael D, Jui, Nathan T., Schüle, Birgitt, Lippard, Stephen J., Tsai, Li-Huei, Krainc, Dimitri, Buchwald, Stephen L., Jaenisch, Rudolf, Lindquist, Susan
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022187/
https://ncbi.nlm.nih.gov/pubmed/24158904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1245296
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items