Genome-scale networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways

Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (α-syn), a protein central to Parkinson’s disease. Genome-wide screen...

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Dades bibliogràfiques
Publicat a:Cell Syst
Autors principals: Khurana, Vikram, Peng, Jian, Chung, Chee Yeun, Auluck, Pavan K., Fanning, Saranna, Tardiff, Daniel F., Bartels, Theresa, Koeva, Martina, Eichhorn, Stephen W., Benyamini, Hadar, Lou, Yali, Nutter-Upham, Andy, Baru, Valeriya, Freyzon, Yelena, Tuncbag, Nurcan, Costanzo, Michael, Luis, Bryan-Joseph San, Schöndorf, David C., Barrasa, M. Inmaculada, Ehsani, Sepehr, Sanjana, Neville, Zhong, Quan, Gasser, Thomas, Bartel, David P., Vidal, Marc, Deleidi, Michela, Boone, Charles, Fraenkel, Ernest, Berger, Bonnie, Lindquist, Susan
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388136/
https://ncbi.nlm.nih.gov/pubmed/28131822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.12.011
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