Genome-scale networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways

Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (α-syn), a protein central to Parkinson’s disease. Genome-wide screen...

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Pubblicato in:Cell Syst
Autori principali: Khurana, Vikram, Peng, Jian, Chung, Chee Yeun, Auluck, Pavan K., Fanning, Saranna, Tardiff, Daniel F., Bartels, Theresa, Koeva, Martina, Eichhorn, Stephen W., Benyamini, Hadar, Lou, Yali, Nutter-Upham, Andy, Baru, Valeriya, Freyzon, Yelena, Tuncbag, Nurcan, Costanzo, Michael, Luis, Bryan-Joseph San, Schöndorf, David C., Barrasa, M. Inmaculada, Ehsani, Sepehr, Sanjana, Neville, Zhong, Quan, Gasser, Thomas, Bartel, David P., Vidal, Marc, Deleidi, Michela, Boone, Charles, Fraenkel, Ernest, Berger, Bonnie, Lindquist, Susan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388136/
https://ncbi.nlm.nih.gov/pubmed/28131822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.12.011
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