FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

Calcineurin is an essential Ca(2+)-dependent phosphatase. Increased calcineurin activity is associated with α-synuclein (α-syn) toxicity, a protein implicated in Parkinson’s Disease (PD) and other neurodegenerative diseases. Calcineurin can be inhibited with Tacrolimus through the recruitment and in...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Caraveo, Gabriela, Soste, Martin, Cappelleti, Valentina, Fanning, Saranna, van Rossum, Damian B., Whitesell, Luke, Huang, Yanmei, Chung, Chee Yeun, Baru, Valeriya, Zaichick, Sofia, Picotti, Paola, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748183/
https://ncbi.nlm.nih.gov/pubmed/29229832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711926115
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