Calcineurin determines toxic versus beneficial responses to α-synuclein

Calcineurin (CN) is a highly conserved Ca(2+)–calmodulin (CaM)-dependent phosphatase that senses Ca(2+) concentrations and transduces that information into cellular responses. Ca(2+) homeostasis is disrupted by α-synuclein (α-syn), a small lipid binding protein whose misfolding and accumulation is a...

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Hlavní autoři: Caraveo, Gabriela, Auluck, Pavan K., Whitesell, Luke, Chung, Chee Yeun, Baru, Valeriya, Mosharov, Eugene V., Yan, Xiaohui, Ben-Johny, Manu, Soste, Martin, Picotti, Paola, Kim, Hanna, Caldwell, Kim A., Caldwell, Guy A., Sulzer, David, Yue, David T., Lindquist, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151770/
https://ncbi.nlm.nih.gov/pubmed/25122673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413201111
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