In situ peroxidase labeling and mass-spectrometry connects alpha-synuclein directly to endocytic trafficking and mRNA metabolism in neurons

Synucleinopathies, including Parkinson’s disease (PD), are associated with the misfolding and mistrafficking of alpha-synuclein (α-syn). Here, using an ascorbate peroxidase (APEX)-based labeling method combined with mass spectrometry, we defined a network of proteins in the immediate vicinity of α-s...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Chung, Chee Yeun, Khurana, Vikram, Yi, Song, Sahni, Nidhi, Loh, Ken H., Auluck, Pavan K., Baru, Valeriya, Udeshi, Namrata D., Freyzon, Yelena, Carr, Steven A., Hill, David E., Vidal, Marc, Ting, Alice Y., Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578869/
https://ncbi.nlm.nih.gov/pubmed/28131823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.01.002
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