In situ peroxidase labeling and mass-spectrometry connects alpha-synuclein directly to endocytic trafficking and mRNA metabolism in neurons

Synucleinopathies, including Parkinson’s disease (PD), are associated with the misfolding and mistrafficking of alpha-synuclein (α-syn). Here, using an ascorbate peroxidase (APEX)-based labeling method combined with mass spectrometry, we defined a network of proteins in the immediate vicinity of α-s...

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Bibliografske podrobnosti
izdano v:Cell Syst
Main Authors: Chung, Chee Yeun, Khurana, Vikram, Yi, Song, Sahni, Nidhi, Loh, Ken H., Auluck, Pavan K., Baru, Valeriya, Udeshi, Namrata D., Freyzon, Yelena, Carr, Steven A., Hill, David E., Vidal, Marc, Ting, Alice Y., Lindquist, Susan
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578869/
https://ncbi.nlm.nih.gov/pubmed/28131823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.01.002
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