Genome-scale networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways

Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (α-syn), a protein central to Parkinson’s disease. Genome-wide screen...

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Vydáno v:Cell Syst
Hlavní autoři: Khurana, Vikram, Peng, Jian, Chung, Chee Yeun, Auluck, Pavan K., Fanning, Saranna, Tardiff, Daniel F., Bartels, Theresa, Koeva, Martina, Eichhorn, Stephen W., Benyamini, Hadar, Lou, Yali, Nutter-Upham, Andy, Baru, Valeriya, Freyzon, Yelena, Tuncbag, Nurcan, Costanzo, Michael, Luis, Bryan-Joseph San, Schöndorf, David C., Barrasa, M. Inmaculada, Ehsani, Sepehr, Sanjana, Neville, Zhong, Quan, Gasser, Thomas, Bartel, David P., Vidal, Marc, Deleidi, Michela, Boone, Charles, Fraenkel, Ernest, Berger, Bonnie, Lindquist, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388136/
https://ncbi.nlm.nih.gov/pubmed/28131822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.12.011
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