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A drug-inducible system for direct reprogramming of human somatic cells to pluripotency

Current approaches to reprogram human somatic cells to pluripotent iPS cells utilize viral transduction of different combinations of transcription factors. These protocols are highly inefficient because only a small fraction of cells carry the appropriate number and stoichiometry of proviral inserti...

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Détails bibliographiques
Auteurs principaux: Hockemeyer, Dirk, Soldner, Frank, Cook, Elizabeth G., Gao, Qing, Mitalipova, Maisam, Jaenisch, Rudolf
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097107/
https://ncbi.nlm.nih.gov/pubmed/18786421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.08.014
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