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A drug-inducible system for direct reprogramming of human somatic cells to pluripotency

Current approaches to reprogram human somatic cells to pluripotent iPS cells utilize viral transduction of different combinations of transcription factors. These protocols are highly inefficient because only a small fraction of cells carry the appropriate number and stoichiometry of proviral inserti...

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Bibliografiske detaljer
Main Authors: Hockemeyer, Dirk, Soldner, Frank, Cook, Elizabeth G., Gao, Qing, Mitalipova, Maisam, Jaenisch, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097107/
https://ncbi.nlm.nih.gov/pubmed/18786421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.08.014
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