A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

The study of induced pluripotency is complicated by the need for infection with high-titer retroviral vectors, which results in genetically heterogeneous cell populations. We generated genetically homogeneous ‘secondary’ somatic cells that carry the reprogramming factors as defined doxycycline (dox)...

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Bibliographic Details
Main Authors: Wernig, Marius, Lengner, Christopher J, Hanna, Jacob, Lodato, Michael A, Steine, Eveline, Foreman, Ruth, Staerk, Judith, Markoulaki, Styliani, Jaenisch, Rudolf
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654269/
https://ncbi.nlm.nih.gov/pubmed/18594521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1483
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