Transgenic Mice with Defined Combinations of Drug Inducible Reprogramming Factors

Drug-inducible lentiviruses encoding Oct4, Sox2, Klf4 and c-Myc were used to derive “primary” iPS cells and segregated through germline transmission generating mice and fibroblasts carrying subsets of the reprogramming factors. Drug treatment of the cells resulted in “secondary” iPS cell derivation...

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Autores principales: Markoulaki, Styliani, Hanna, Jacob, Beard, Caroline, Carey, Bryce W., Cheng, Albert W., Lengner, Christopher J., Dausman, Jessica A., Fu, Dongdong, Gao, Qing, Wu, Su, Cassady, John P., Jaenisch, Rudolf
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654270/
https://ncbi.nlm.nih.gov/pubmed/19151700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1520
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