Transgenic Mice with Defined Combinations of Drug Inducible Reprogramming Factors

Drug-inducible lentiviruses encoding Oct4, Sox2, Klf4 and c-Myc were used to derive “primary” iPS cells and segregated through germline transmission generating mice and fibroblasts carrying subsets of the reprogramming factors. Drug treatment of the cells resulted in “secondary” iPS cell derivation...

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Detalhes bibliográficos
Main Authors: Markoulaki, Styliani, Hanna, Jacob, Beard, Caroline, Carey, Bryce W., Cheng, Albert W., Lengner, Christopher J., Dausman, Jessica A., Fu, Dongdong, Gao, Qing, Wu, Su, Cassady, John P., Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654270/
https://ncbi.nlm.nih.gov/pubmed/19151700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1520
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