Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells

Pluripotency can be induced in differentiated murine and human cells by retroviral transduction of Oct4, Sox2, Klf4 and c-Myc. We have devised a reprogramming strategy in which these four transcription factors are expressed from doxycycline (dox) inducible lentiviral vectors. Using these inducible c...

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Main Authors: Brambrink, Tobias, Foreman, Ruth, Welstead, G. Grant, Lengner, Christopher J., Wernig, Marius, Suh, Heikyung, Jaenisch, Rudolf
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276627/
https://ncbi.nlm.nih.gov/pubmed/18371436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.01.004
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