Role of Mitochondrial Toxicity in BMS-986094-Induced Toxicity

Por Feng, Joy Y., Tay, Chin H., Ray, Adrian S.
Publicado no Toxicol Sci (2017)

Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase

Por Gaur, Vineet, Vyas, Rajan, Fowler, Jason D., Efthimiopoulos, Georgia, Feng, Joy Y., Suo, Zucai
Publicado em 2014

The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study

Por Feng, Joy Y, Ly, John K, Myrick, Florence, Goodman, Derrick, White, Kirsten L, Svarovskaia, Evguenia S, Borroto-Esoda, Katyna, Miller, Michael D
Publicado em 2009

Relationship between Antiviral Activity and Host Toxicity: Comparison of the Incorporation Efficiencies of 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine-Triphosphate Analogs by Human Immu...

Por Feng, Joy Y., Murakami, Eisuke, Zorca, Suzana M., Johnson, Allison A., Johnson, Kenneth A., Schinazi, Raymond F., Furman, Phillip A., Anderson, Karen S.
Publicado em 2004

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs

Por Barauskas, Ona, Xing, Weimei, Aguayo, Esmeralda, Willkom, Madeleine, Sapre, Annapurna, Clarke, Michael, Birkus, Gabriel, Schultz, Brian E., Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y.
Publicado no PLoS One (2017)

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors

Por Xing, Weimei, Barauskas, Ona, Kirschberg, Thorsten, Niedziela-Majka, Anita, Clarke, Michael, Birkus, Gabriel, Weissburg, Perry, Liu, Xiaohong, Schultz, Brian E., Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y.
Publicado no PLoS One (2017)

Bifunctional Inhibition of HIV-1 Reverse Transcriptase: A First Step in Designing a Bifunctional Triphosphate()

Por Piao, Dongyuan, Basavapathruni, Aravind, Iyidogan, Pinar, Dai, Guangxiu, Hinz, Wolfgang, Ray, Adrian S., Murakami, Eisuke, Feng, Joy Y., You, Fei, Dutschman, Ginger E., Austin, David J., Parker, Kathlyn A., Anderson, Karen S.
Publicado em 2012

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

Por Feng, Joy Y., Xu, Yili, Barauskas, Ona, Perry, Jason K., Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E., Sakowicz, Roman, Ray, Adrian S.
Publicado no Antimicrob Agents Chemother (2016)

Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

Por Furman, Phillip A., Jeffrey, Jerry, Kiefer, Laura L., Feng, Joy Y., Anderson, Karen S., Borroto-Esoda, Katyna, Hill, Edgar, Copeland, William C., Chu, Chung K., Sommadossi, Jean-Pierre, Liberman, Irina, Schinazi, Raymond F., Painter, George R.
Publicado em 2001

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

Por Das, Kalyan, Bandwar, Rajiv P., White, Kirsten L., Feng, Joy Y., Sarafianos, Stefan G., Tuske, Steven, Tu, Xiongying, Clark, Arthur D., Boyer, Paul L., Hou, Xiaorong, Gaffney, Barbara L., Jones, Roger A., Miller, Michael D., Hughes, Stephen H., Arnold, Eddy
Publicado em 2009

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

Por Arnold, Jamie J., Sharma, Suresh D., Feng, Joy Y., Ray, Adrian S., Smidansky, Eric D., Kireeva, Maria L., Cho, Aesop, Perry, Jason, Vela, Jennifer E., Park, Yeojin, Xu, Yili, Tian, Yang, Babusis, Darius, Barauskus, Ona, Peterson, Blake R., Gnatt, Averell, Kashlev, Mikhail, Zhong, Weidong, Cameron, Craig E.
Publicado em 2012

Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug

Por Feng, Joy Y., Cheng, Guofeng, Perry, Jason, Barauskas, Ona, Xu, Yili, Fenaux, Martijn, Eng, Stacey, Tirunagari, Neeraj, Peng, Betty, Yu, Mei, Tian, Yang, Lee, Yu-Jen, Stepan, George, Lagpacan, Leanna L., Jin, Debi, Hung, Magdeleine, Ku, Karin S., Han, Bin, Kitrinos, Kathryn, Perron, Michel, Birkus, Gabriel, Wong, Kelly A., Zhong, Weidong, Kim, Choung U., Carey, Anne, Cho, Aesop, Ray, Adrian S.
Publicado em 2014

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Por Sheahan, Timothy P., Sims, Amy C., Graham, Rachel L., Menachery, Vineet D., Gralinski, Lisa E., Case, James B., Leist, Sarah R., Pyrc, Krzysztof, Feng, Joy Y., Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O., Mackman, Richard L., Spahn, Jamie E., Palmiotti, Christopher A., Siegel, Dustin, Ray, Adrian S., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.
Publicado no Sci Transl Med (2017)

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Por Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina
Publicado no Nature (2016)