Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

(−)-β-d-2,6-Diaminopurine dioxolane (DAPD), is a nucleoside reverse transcriptase (RT) inhibitor with activity against human immunodeficiency virus type 1 (HIV-1). DAPD, which was designed as a water-soluble prodrug, is deaminated by adenosine deaminase to give (−)-β-d-dioxolane guanine (DXG). By us...

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Detalles Bibliográficos
Autores principales: Furman, Phillip A., Jeffrey, Jerry, Kiefer, Laura L., Feng, Joy Y., Anderson, Karen S., Borroto-Esoda, Katyna, Hill, Edgar, Copeland, William C., Chu, Chung K., Sommadossi, Jean-Pierre, Liberman, Irina, Schinazi, Raymond F., Painter, George R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC90254/
https://ncbi.nlm.nih.gov/pubmed/11120959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.158-165.2001
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