Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

(−)-β-d-2,6-Diaminopurine dioxolane (DAPD), is a nucleoside reverse transcriptase (RT) inhibitor with activity against human immunodeficiency virus type 1 (HIV-1). DAPD, which was designed as a water-soluble prodrug, is deaminated by adenosine deaminase to give (−)-β-d-dioxolane guanine (DXG). By us...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Furman, Phillip A., Jeffrey, Jerry, Kiefer, Laura L., Feng, Joy Y., Anderson, Karen S., Borroto-Esoda, Katyna, Hill, Edgar, Copeland, William C., Chu, Chung K., Sommadossi, Jean-Pierre, Liberman, Irina, Schinazi, Raymond F., Painter, George R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90254/
https://ncbi.nlm.nih.gov/pubmed/11120959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.158-165.2001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados