Mutations of the Woodchuck Hepatitis Virus Polymerase Gene That Confer Resistance to Lamivudine and 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil

Administration of either lamivudine (2′-deoxy-3′-thiacytidine) or l-FMAU (2′-fluoro-5-methyl-β-l-arabinofuranosyluracil) to woodchucks chronically infected with woodchuck hepatitis virus (WHV) induces a transient decline in virus titers. However, within 6 to 12 months, virus titers begin to increase...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Yamamoto, Toshiki, Litwin, Samuel, Zhou, Tianlun, Zhu, Yuao, Condreay, Lynn, Furman, Phillip, Mason, William S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Vaccines and Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135858/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11773397/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.3.1213-1223.2002
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