Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors

Por Birkus, Gabriel, Hitchcock, Michael J. M., Cihlar, Tomas
Publicado em 2002

Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases α, δ, and ɛ*

Por Birkuš, Gabriel, Hájek, Miroslav, Kramata, Pavel, Votruba, Ivan, Holý, Antonín, Otová, Berta
Publicado em 2002

Molecular Determinants of GS-9620-Dependent TLR7 Activation

Por Rebbapragada, Indrani, Birkus, Gabriel, Perry, Jason, Xing, Weimei, Kwon, HyockJoo, Pflanz, Stefan
Publicado no PLoS One (2016)

Multiple Classes of Antiviral Agents Exhibit In Vitro Activity against Human Rhinovirus Type C

Por Mello, Chris, Aguayo, Esmeralda, Rodriguez, Madeleine, Lee, Gary, Jordan, Robert, Cihlar, Tomas, Birkus, Gabriel
Publicado em 2014

Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Antipapillomavirus Agent GS-9191

Por Birkus, Gabriel, Kutty, Nilima, Frey, Christian R., Shribata, Riri, Chou, Tsuifen, Wagner, Carston, McDermott, Martin, Cihlar, Tomas
Publicado em 2011

Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir

Por Stray, Kirsten M., Bam, Rujuta A., Birkus, Gabriel, Hao, Jia, Lepist, Eve-Irene, Yant, Stephen R., Ray, Adrian S., Cihlar, Tomas
Publicado em 2013

Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors

Por Birkus, Gabriel, Bam, Rujuta A., Willkom, Madeleine, Frey, Christian R., Tsai, Luong, Stray, Kirsten M., Yant, Stephen R., Cihlar, Tomas
Publicado no Antimicrob Agents Chemother (2015)

Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs

Por Alian, Akram, Griner, Sarah L., Chiang, Vicki, Tsiang, Manuel, Jones, Gregg, Birkus, Gabriel, Geleziunas, Romas, Leavitt, Andrew D., Stroud, Robert M.
Publicado em 2009

Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131

Por Birkus, Gabriel, Wang, Ruth, Liu, Xiaohong, Kutty, Nilima, MacArthur, Holly, Cihlar, Tomas, Gibbs, Craig, Swaminathan, Swami, Lee, William, McDermott, Martin
Publicado em 2007

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat

Por Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S
Publicado em 2014

GS-9191 Is a Novel Topical Prodrug of the Nucleotide Analog 9-(2-Phosphonylmethoxyethyl)Guanine with Antiproliferative Activity and Possible Utility in the Treatment of Human Papil...

Por Wolfgang, Grushenka H. I., Shibata, Riri, Wang, Jianying, Ray, Adrian S., Wu, Sylvia, Doerrfler, Edward, Reiser, Hans, Lee, William A., Birkus, Gabriel, Christensen, Neil D., Andrei, Graciela, Snoeck, Robert
Publicado em 2009

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

Por Murakami, Eisuke, Wang, Ting, Babusis, Darius, Lepist, Eve-Irene, Sauer, Dorothea, Park, Yeojin, Vela, Jennifer E., Shih, Robert, Birkus, Gabriel, Stefanidis, Dimitrios, Kim, Choung U., Cho, Aesop, Ray, Adrian S.
Publicado em 2014

Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug

Por Feng, Joy Y., Cheng, Guofeng, Perry, Jason, Barauskas, Ona, Xu, Yili, Fenaux, Martijn, Eng, Stacey, Tirunagari, Neeraj, Peng, Betty, Yu, Mei, Tian, Yang, Lee, Yu-Jen, Stepan, George, Lagpacan, Leanna L., Jin, Debi, Hung, Magdeleine, Ku, Karin S., Han, Bin, Kitrinos, Kathryn, Perron, Michel, Birkus, Gabriel, Wong, Kelly A., Zhong, Weidong, Kim, Choung U., Carey, Anne, Cho, Aesop, Ray, Adrian S.
Publicado em 2014