Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131

GS-7340 and GS-9131 {9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-propyl]adenine and 9-(R)-4′-(R)-[[[(S)-1-[(ethoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-2′-fluoro-1′-furanyladenine, respectively} are novel alkylalaninyl phenyl ester prodrugs of tenofovi...

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Detalhes bibliográficos
Main Authors: Birkus, Gabriel, Wang, Ruth, Liu, Xiaohong, Kutty, Nilima, MacArthur, Holly, Cihlar, Tomas, Gibbs, Craig, Swaminathan, Swami, Lee, William, McDermott, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797775/
https://ncbi.nlm.nih.gov/pubmed/17145787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00968-06
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