Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent

GS-9131 is a phosphonoamidate prodrug of the novel ribose-modified phosphonate nucleotide analog GS-9148 that demonstrates potent anti-human immunodeficiency virus type 1 (HIV-1) activity and an excellent resistance profile in vitro. Prodrug moieties were optimized for the efficient delivery of GS-9...

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Autors principals: Ray, Adrian S., Vela, Jennifer E., Boojamra, Constantine G., Zhang, Lijun, Hui, Hon, Callebaut, Christian, Stray, Kirsten, Lin, Kuei-Ying, Gao, Ying, Mackman, Richard L., Cihlar, Tomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224749/
https://ncbi.nlm.nih.gov/pubmed/18056281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01209-07
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