Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

The anti-hepatitis C virus nucleotide prodrug GS-6620 employs a double-prodrug approach, with l-alanine-isopropyl ester and phenol moieties attached to the 5′-phosphate that release the nucleoside monophosphate in hepatocytes and a 3′-isobutyryl ester added to improve permeability and oral bioavaila...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Murakami, Eisuke, Wang, Ting, Babusis, Darius, Lepist, Eve-Irene, Sauer, Dorothea, Park, Yeojin, Vela, Jennifer E., Shih, Robert, Birkus, Gabriel, Stefanidis, Dimitrios, Kim, Choung U., Cho, Aesop, Ray, Adrian S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023801/
https://ncbi.nlm.nih.gov/pubmed/24419340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02350-13
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados