Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine

Por Jones, Scott A., Murakami, Eisuke, Delaney, William, Furman, Phillip, Hu, Jianming
Publicado em 2013

Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine

Por Jones, Scott A., Murakami, Eisuke, Delaney, William, Furman, Phillip, Hu, Jianming
Publicado em 2013

Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy

Por Murakami, Eisuke, Wang, Ting, Park, Yeojin, Hao, Jia, Lepist, Eve-Irene, Babusis, Darius, Ray, Adrian S.
Publicado no Antimicrob Agents Chemother (2015)

Relationship between Antiviral Activity and Host Toxicity: Comparison of the Incorporation Efficiencies of 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine-Triphosphate Analogs by Human Immu...

Por Feng, Joy Y., Murakami, Eisuke, Zorca, Suzana M., Johnson, Allison A., Johnson, Kenneth A., Schinazi, Raymond F., Furman, Phillip A., Anderson, Karen S.
Publicado em 2004

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

Por Mosley, Ralph T., Edwards, Thomas E., Murakami, Eisuke, Lam, Angela M., Grice, Rena L., Du, Jinfa, Sofia, Michael J., Furman, Philip A., Otto, Michael J.
Publicado em 2012

The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Po...

Por Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M., Whitaker, Tony, Nachman, Tammy, Sofia, Michael A., Wang, Peiyuan, Otto, Michael J., Furman, Phillip A.
Publicado em 2008

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

Por Lam, Angela M., Edwards, Thomas E., Mosley, Ralph T., Murakami, Eisuke, Bansal, Shalini, Lugo, Christopher, Bao, Haiying, Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Publicado no Antimicrob Agents Chemother (2014)

Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay

Por Yoshimi, Satoshi, Ochi, Hidenori, Murakami, Eisuke, Uchida, Takuro, Kan, Hiromi, Akamatsu, Sakura, Hayes, C. Nelson, Abe, Hiromi, Miki, Daiki, Hiraga, Nobuhiko, Imamura, Michio, Aikata, Hiroshi, Chayama, Kazuaki
Publicado no PLoS One (2015)

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

Por Murakami, Eisuke, Wang, Ting, Babusis, Darius, Lepist, Eve-Irene, Sauer, Dorothea, Park, Yeojin, Vela, Jennifer E., Shih, Robert, Birkus, Gabriel, Stefanidis, Dimitrios, Kim, Choung U., Cho, Aesop, Ray, Adrian S.
Publicado em 2014

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

Por Murakami, Eisuke, Bao, Haiying, Ramesh, Mangala, McBrayer, Tamara R., Whitaker, Tony, Micolochick Steuer, Holly M., Schinazi, Raymond F., Stuyver, Lieven J., Obikhod, Aleksandr, Otto, Michael J., Furman, Phillip A.
Publicado em 2007

Bifunctional Inhibition of HIV-1 Reverse Transcriptase: A First Step in Designing a Bifunctional Triphosphate()

Por Piao, Dongyuan, Basavapathruni, Aravind, Iyidogan, Pinar, Dai, Guangxiu, Hinz, Wolfgang, Ray, Adrian S., Murakami, Eisuke, Feng, Joy Y., You, Fei, Dutschman, Ginger E., Austin, David J., Parker, Kathlyn A., Anderson, Karen S.
Publicado em 2012

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

Por Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Publicado em 2010

Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Por Ray, Adrian S., Hernandez-Santiago, Brenda I., Mathew, Judy S., Murakami, Eisuke, Bozeman, Carey, Xie, Meng-Yu, Dutschman, Ginger E., Gullen, Elizabeth, Yang, Zhenjun, Hurwitz, Selwyn, Cheng, Yung-Chi, Chu, Chung K., McClure, Harold, Schinazi, Raymond F., Anderson, Karen S.
Publicado em 2005

Ultradeep Sequencing Study of Chronic Hepatitis C Virus Genotype 1 Infection in Patients Treated with Daclatasvir, Peginterferon, and Ribavirin

Por Murakami, Eisuke, Imamura, Michio, Hayes, C. Nelson, Abe, Hiromi, Hiraga, Nobuhiko, Honda, Yoji, Ono, Atsushi, Kosaka, Keiichi, Kawaoka, Tomokazu, Tsuge, Masataka, Aikata, Hiroshi, Takahashi, Shoichi, Miki, Daiki, Ochi, Hidenori, Matsui, Hirotaka, Kanai, Akinori, Inaba, Toshiya, McPhee, Fiona, Chayama, Kazuaki
Publicado em 2014

Activity and the Metabolic Activation Pathway of the Potent and Selective Hepatitis C Virus Pronucleotide Inhibitor PSI-353661

Por Furman, Phillip A., Murakami, Eisuke, Niu, Congrong, Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Bao, Haiying, Tolstykh, Tatiana, Steuer, Holly Micolochick, Keilman, Meg, Zennou, Veronique, Bourne, Nigel, Veselenak, Ronald L., Chang, Wonsuk, Ross, Bruce S., Du, Jinfa, Otto, Michael J., Sofia, Michael J.
Publicado em 2011

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

Por Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, Zennou, Veronique, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Keilman, Meg, Bao, Haiying, Bourne, Nigel, Veselenak, Ronald L., Reddy, P. Ganapati, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
Publicado em 2011

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

Por Niu, Congrong, Tolstykh, Tatiana, Bao, Haiying, Park, Yeojin, Babusis, Darius, Lam, Angela M., Bansal, Shalini, Du, Jinfa, Chang, Wonsuk, Reddy, P. Ganapati, Zhang, Hai-Ren, Woolley, Joseph, Wang, Li-Quan, Chao, Piyun B., Ray, Adrian S., Otto, Michael J., Sofia, Michael J., Furman, Phillip A., Murakami, Eisuke
Publicado em 2012

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

Por Lam, Angela M., Murakami, Eisuke, Espiritu, Christine, Steuer, Holly M. Micolochick, Niu, Congrong, Keilman, Meg, Bao, Haiying, Zennou, Veronique, Bourne, Nigel, Julander, Justin G., Morrey, John D., Smee, Donald F., Frick, David N., Heck, Julie A., Wang, Peiyuan, Nagarathnam, Dhanapalan, Ross, Bruce S., Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
Publicado em 2010