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Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine
To better understand the importance of the oxygen in the ribose ring of planar unsaturated nucleoside analogs that target human immunodeficiency virus (HIV), a 6-cyclopropyl-substituted prodrug of 2′,3′-didehydro-2′,3′-dideoxyguanosine (cyclo-d4G) was synthesized, and its cellular metabolism, antivi...
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Autors principals: | , , , , , , , , , , , , , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
American Society for Microbiology
2005
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087621/ https://ncbi.nlm.nih.gov/pubmed/15855524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1994-2001.2005 |
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