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Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

To better understand the importance of the oxygen in the ribose ring of planar unsaturated nucleoside analogs that target human immunodeficiency virus (HIV), a 6-cyclopropyl-substituted prodrug of 2′,3′-didehydro-2′,3′-dideoxyguanosine (cyclo-d4G) was synthesized, and its cellular metabolism, antivi...

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Autors principals: Ray, Adrian S., Hernandez-Santiago, Brenda I., Mathew, Judy S., Murakami, Eisuke, Bozeman, Carey, Xie, Meng-Yu, Dutschman, Ginger E., Gullen, Elizabeth, Yang, Zhenjun, Hurwitz, Selwyn, Cheng, Yung-Chi, Chu, Chung K., McClure, Harold, Schinazi, Raymond F., Anderson, Karen S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087621/
https://ncbi.nlm.nih.gov/pubmed/15855524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1994-2001.2005
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