Role of Purine Nucleoside Phosphorylase in Interactions between 2′,3′-Dideoxyinosine and Allopurinol, Ganciclovir, or Tenofovir

par Ray, Adrian S., Olson, Loren, Fridland, Arnold
Publié 2004

Role of Mitochondrial Toxicity in BMS-986094-Induced Toxicity

par Feng, Joy Y., Tay, Chin H., Ray, Adrian S.
Publié dans Toxicol Sci (2017)

Novel Use of a Guanosine Prodrug Approach To Convert 2′,3′-Didehydro-2′,3′-Dideoxyguanosine into a Viable Antiviral Agent

par Ray, Adrian S., Yang, Zhenjun, Chu, Chung K., Anderson, Karen S.
Publié 2002

Viability of primary osteoblasts after treatment with tenofovir alafenamide: Lack of cytotoxicity at clinically relevant drug concentrations

par Callebaut, Christian, Liu, Yang, Babusis, Darius, Ray, Adrian, Miller, Michael, Kitrinos, Kathryn
Publié dans PLoS One (2017)

Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy

par Murakami, Eisuke, Wang, Ting, Park, Yeojin, Hao, Jia, Lepist, Eve-Irene, Babusis, Darius, Ray, Adrian S.
Publié dans Antimicrob Agents Chemother (2015)

Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus

par Delaney, William E., Ray, Adrian S., Yang, Huiling, Qi, Xiaoping, Xiong, Shelly, Zhu, Yuao, Miller, Michael D.
Publié 2006

Novel Nucleotide Human Immunodeficiency Virus Reverse Transcriptase Inhibitor GS-9148 with a Low Nephrotoxic Potential: Characterization of Renal Transport and Accumulation

par Cihlar, Tomas, LaFlamme, Genevieve, Fisher, Robyn, Carey, Anne C., Vela, Jennifer E., Mackman, Richard, Ray, Adrian S.
Publié 2009

Intracellular Nucleotide Levels during Coadministration of Tenofovir Disoproxil Fumarate and Didanosine in HIV-1-Infected Patients

par Hawkins, Trevor, Veikley, Wenoah, Durand-Gasselin, Lucie, Babusis, Darius, Reddy, Y. Sunila, Flaherty, John F., Ray, Adrian S.
Publié 2011

Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro

par Lepist, Eve-Irene, Phan, Truc K., Roy, Anupma, Tong, Leah, MacLennan, Kelly, Murray, Bernard, Ray, Adrian S.
Publié 2012

GS-9219/VDC-1101 - a prodrug of the acyclic nucleotide PMEG has antitumor activity inspontaneous canine multiple myeloma

par Thamm, Douglas H, Vail, David M, Kurzman, Ilene D, Babusis, Darius, Ray, Adrian S, Sousa-Powers, Noel, Tumas, Daniel B
Publié 2014

Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir

par Stray, Kirsten M., Bam, Rujuta A., Birkus, Gabriel, Hao, Jia, Lepist, Eve-Irene, Yant, Stephen R., Ray, Adrian S., Cihlar, Tomas
Publié 2013

Evaluation of the Endothelin Receptor Antagonists Ambrisentan, Bosentan, Macitentan, and Sitaxsentan as Hepatobiliary Transporter Inhibitors and Substrates in Sandwich-Cultured Hum...

par Lepist, Eve-Irene, Gillies, Hunter, Smith, William, Hao, Jia, Hubert, Cassandra, St. Claire, Robert L., Brouwer, Kenneth R., Ray, Adrian S.
Publié 2014

Effects of Human Immunodeficiency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro

par Tong, Leah, Phan, Truc K., Robinson, Kelly L., Babusis, Darius, Strab, Robert, Bhoopathy, Siddhartha, Hidalgo, Ismael J., Rhodes, Gerald R., Ray, Adrian S.
Publié 2007

Nucleotide Analog Prodrug, Tenofovir Disoproxil, Enhances Lymphoid Cell Loading Following Oral Administration in Monkeys

par Durand-Gasselin, Lucie, Van Rompay, Koen K.A., Vela, Jennifer E., Henne, Ilana N., Lee, William A., Rhodes, Gerry R., Ray, Adrian S.
Publié 2009

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

par Cho, Aesop, Saunders, Oliver L., Butler, Thomas, Zhang, Lijun, Xu, Jie, Vela, Jennifer E., Feng, Joy Y., Ray, Adrian S., Kim, Choung U.
Publié dans Bioorg Med Chem Lett (2012)

Sofosbuvir and Ribavirin Liver Pharmacokinetics in Patients Infected with Hepatitis C Virus

par Babusis, Darius, Curry, Michael P., Kirby, Brian, Park, Yeojin, Murakami, Eisuke, Wang, Ting, Mathias, Anita, Afdhal, Nezam, McHutchison, John G., Ray, Adrian S.
Publié dans Antimicrob Agents Chemother (2018)

Mechanism of Active Renal Tubular Efflux of Tenofovir

par Ray, Adrian S., Cihlar, Tomas, Robinson, Kelly L., Tong, Leah, Vela, Jennifer E., Fuller, Michael D., Wieman, Lani M., Eisenberg, Eugene J., Rhodes, Gerry R.
Publié 2006

Compared to Subcutaneous Tenofovir, Oral Tenofovir Disoproxyl Fumarate Administration Preferentially Concentrates the Drug into Gut-Associated Lymphoid Cells in Simian Immunodefici...

par Van Rompay, Koen K. A., Babusis, Darius, Abbott, Zachary, Geng, Yongzhi, Jayashankar, Kartika, Johnson, Jeffrey A., Lipscomb, Jonathan, Heneine, Walid, Abel, Kristina, Ray, Adrian S.
Publié 2012

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat

par Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S
Publié 2014

Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent

par Ray, Adrian S., Vela, Jennifer E., Boojamra, Constantine G., Zhang, Lijun, Hui, Hon, Callebaut, Christian, Stray, Kirsten, Lin, Kuei-Ying, Gao, Ying, Mackman, Richard L., Cihlar, Tomas
Publié 2008