GF120918, a P-Glycoprotein Modulator, Increases the Concentration of Unbound Amprenavir in the Central Nervous System in Rats

par Edwards, Jeffrey E., Brouwer, Kenneth R., McNamara, Patrick J.
Publié 2002

Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes

par Wolf, Kristina K., Brouwer, Kenneth R., Pollack, Gary M., Brouwer, Kim L.R.
Publié 2008

Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes

par Guo, Cen, Brouwer, Kenneth R., Stewart, Paul W., Moseley, Caroline, Brouwer, Kim L.R.
Publié dans J Pharm Pharm Sci (2019)

Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simula...

par Guo, Cen, Yang, Kyunghee, Brouwer, Kenneth R., St. Claire, Robert L., Brouwer, Kim L.R.
Publié dans J Pharmacol Exp Ther (2016)

Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms

par Guo, Cen, LaCerte, Carl, Edwards, Jeffrey E., Brouwer, Kenneth R., Brouwer, Kim L. R.
Publié dans J Pharmacol Exp Ther (2018)

Prediction of Hepatic Efflux Transporter-mediated Drug Interactions: When is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?

par Guo, Cen, Yang, Kyunghee, Liao, Mingxiang, Xia, Cindy Q., Brouwer, Kenneth R., Brouwer, Kim L.R.
Publié dans J Pharm Sci (2017)

Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models

par Zhang, Yuanyuan, LaCerte, Carl, Kansra, Sanjay, Jackson, Jonathan P., Brouwer, Kenneth R., Edwards, Jeffrey E.
Publié dans Pharmacol Res Perspect (2017)

Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich‐cultured human hepatocytes

par Zhang, Yuanyuan, Jackson, Jonathan P., St. Claire, Robert L., Freeman, Kimberly, Brouwer, Kenneth R., Edwards, Jeffrey E.
Publié dans Pharmacol Res Perspect (2017)

Evaluation of the Endothelin Receptor Antagonists Ambrisentan, Bosentan, Macitentan, and Sitaxsentan as Hepatobiliary Transporter Inhibitors and Substrates in Sandwich-Cultured Hum...

par Lepist, Eve-Irene, Gillies, Hunter, Smith, William, Hao, Jia, Hubert, Cassandra, St. Claire, Robert L., Brouwer, Kenneth R., Ray, Adrian S.
Publié 2014

Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes

par Lu, Yang, Slizgi, Jason R., Brouwer, Kenneth R., St. Claire, Robert L., Freeman, Kimberly M., Pan, Maxwell, Brock, William J., Brouwer, Kim L. R.
Publié dans Drug Metab Dispos (2016)

Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

par Slizgi, Jason R., Lu, Yang, Brouwer, Kenneth R., St. Claire, Robert L., Freeman, Kimberly M., Pan, Maxwell, Brock, William J., Brouwer, Kim L. R.
Publié dans Toxicol Sci (2016)

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

par Kenna, J. Gerry, Taskar, Kunal S., Battista, Christina, Bourdet, David L., Brouwer, Kim L.R., Brouwer, Kenneth R., Dai, David, Funk, Christoph, Hafey, Michael J., Lai, Yurong, Maher, Jonathan, Pak, Y. Anne, Pedersen, Jenny M., Polli, Joseph W., Rodrigues, A. David, Watkins, Paul B., Yang, Kyunghee, Yucha, Robert W.
Publié dans Clin Pharmacol Ther (2018)

Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters

par Sissung, Tristan M., Huang, Phoebe A., Hauke, Ralph J., McCrea, Edel M., Peer, Cody J., Barbier, Roberto H., Strope, Jonathan D., Ley, Ariel M., Zhang, Mary, Hong, Julie A., Venzon, David, Jackson, Jonathan P., Brouwer, Kenneth R., Grohar, Patrick, Glod, Jon, Widemann, Brigitte C., Heller, Theo, Schrump, David S., Figg, William D.
Publié dans Mol Pharmacol (2019)