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Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models
Obeticholic acid (OCA) is a semisynthetic farnesoid X receptor (FXR) agonist, an analogue of chenodeoxycholic acid (CDCA) which is indicated for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA). OCA efficiently inhibits bile acid synthesis and promot...
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| Publicado no: | Pharmacol Res Perspect |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5723701/ https://ncbi.nlm.nih.gov/pubmed/29226620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.368 |
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