FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

BACKGROUND & AIMS: Intestinal bacteria can modify the composition of bile acids and bile acids, which are regulated by the farnesoid X receptor (FXR), affect the survival and growth of gut bacteria. We studied the effects of obeticholic acid (OCA), a bile acid analog and FXR agonist, on the inte...

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Bibliografiske detaljer
Udgivet i:Gastroenterology
Main Authors: Friedman, Elliot S., Li, Yun, Shen, Ting-Chin David, Jiang, Jack, Chau, Lillian, Adorini, Luciano, Babakhani, Farah, Edwards, Jeffrey, Shapiro, David, Zhao, Chunyu, Carr, Rotonya M., Bittinger, Kyle, Li, Hongzhe, Wu, Gary D.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279623/
https://ncbi.nlm.nih.gov/pubmed/30144429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.08.022
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