Metabolic Profile of Obeticholic Acid and Endogenous Bile Acids in Rats with Decompensated Liver Cirrhosis

Obeticholic acid (OCA) is a semisynthetic bile acid (BA) analog and potent farnesoid X receptor agonist approved to treat cholestasis. We evaluated the biodistribution and metabolism of OCA administered to carbon tetrachloride‐induced cirrhotic rats. This was to ascertain if plasma and hepatic conce...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Roda, A, Aldini, R, Camborata, C, Spinozzi, S, Franco, P, Cont, M, D'Errico, A, Vasuri, F, Degiovanni, A, Maroni, L, Adorini, L
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504479/
https://ncbi.nlm.nih.gov/pubmed/28411380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12468
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