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Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage
Obeticholic acid (OCA), a semisynthetic bile acid, is a selective and potent farnesoid X receptor (FXR) agonist in development for the treatment of chronic nonviral liver diseases. Physiologic pharmacokinetic models have been previously used to describe the absorption, distribution, metabolism, and...
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| Publicado no: | Clin Transl Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5351006/ https://ncbi.nlm.nih.gov/pubmed/27743502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12421 |
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