FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

Hepatic inflammation drives hepatic stellate cells (HSC), resulting in liver fibrosis. The Farnesoid-X receptor (FXR) antagonizes inflammation through NF-κB inhibition. We investigated preventive and therapeutic effects of FXR agonist obeticholic acid (OCA) on hepatic inflammation and fibrosis in to...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Verbeke, Len, Mannaerts, Inge, Schierwagen, Robert, Govaere, Olivier, Klein, Sabine, Vander Elst, Ingrid, Windmolders, Petra, Farre, Ricard, Wenes, Mathias, Mazzone, Massimiliano, Nevens, Frederik, van Grunsven, Leo A., Trebicka, Jonel, Laleman, Wim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025787/
https://ncbi.nlm.nih.gov/pubmed/27634375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33453
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados