Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

Tolvaptan is a vasopressin V(2)-receptor antagonist that has shown promise in treating Autosomal Dominant Polycystic Kidney Disease (ADPKD). Tolvaptan was, however, associated with liver injury in some ADPKD patients. Inhibition of bile acid transporters may be contributing factors to drug-induced l...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Toxicol Sci
Egile Nagusiak: Slizgi, Jason R., Lu, Yang, Brouwer, Kenneth R., St. Claire, Robert L., Freeman, Kimberly M., Pan, Maxwell, Brock, William J., Brouwer, Kim L. R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
Tolvaptan Inhibition of Bile Acid Transporters and Liver Injury
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169477/
https://ncbi.nlm.nih.gov/pubmed/26507107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv231
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