Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes

Tolvaptan is a selective V(2)-receptor antagonist primarily metabolized by CYP 3A. The present study investigated the hepatocellular disposition of tolvaptan and the generated tolvaptan metabolites, DM-4103 and DM-4107, as well as the potential for drug-drug interactions (DDIs) with metabolic and tr...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Lu, Yang, Slizgi, Jason R., Brouwer, Kenneth R., St. Claire, Robert L., Freeman, Kimberly M., Pan, Maxwell, Brock, William J., Brouwer, Kim L. R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885486/
https://ncbi.nlm.nih.gov/pubmed/27013400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.067629
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