Combination Lopinavir and Ritonavir Alter Exogenous and Endogenous Bile Acid Disposition in Sandwich-Cultured Rat Hepatocytes

Inhibition of the bile salt export pump (BSEP) can cause intracellular accumulation of bile acids and is a risk factor for drug-induced liver injury in humans. Antiretroviral protease inhibitors lopinavir (LPV) and ritonavir (RTV) are reported BSEP inhibitors. However, the consequences of LPV and RT...

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Bibliographic Details
Main Authors: Griffin, LaToya M., Watkins, Paul B., Perry, Cassandra H., St. Claire, Robert L., Brouwer, Kim L. R.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533430/
https://ncbi.nlm.nih.gov/pubmed/23091188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.047225
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