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Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes
Estradiol-17β-glucuronide (E(2)17G) is an estrogen metabolite that has cholestatic properties. In humans, circulating E(2)17G is transported into hepatocytes by organic anion transporting polypeptides (OATPs) and is excreted into bile by multidrug-resistance associated protein 2 (MRP2). E(2)17G is a...
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| Publicado no: | Drug Metab Dispos |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6978695/ https://ncbi.nlm.nih.gov/pubmed/31744810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088898 |
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