Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

Transporter-mediated alterations in bile acid disposition may have significant toxicological implications. Current methods to predict interactions are limited by the interplay of multiple transporters, absence of protein in the experimental system, and inaccurate estimates of inhibitor concentration...

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Foilsithe in:J Pharmacol Exp Ther
Main Authors: Guo, Cen, Yang, Kyunghee, Brouwer, Kenneth R., St. Claire, Robert L., Brouwer, Kim L.R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2016
Ábhair:
Metabolism, Transport, and Pharmacogenomics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959093/
https://ncbi.nlm.nih.gov/pubmed/27233294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.231928
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