Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

Transporter-mediated alterations in bile acid disposition may have significant toxicological implications. Current methods to predict interactions are limited by the interplay of multiple transporters, absence of protein in the experimental system, and inaccurate estimates of inhibitor concentration...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Guo, Cen, Yang, Kyunghee, Brouwer, Kenneth R., St. Claire, Robert L., Brouwer, Kim L.R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2016
Schlagworte:
Metabolism, Transport, and Pharmacogenomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959093/
https://ncbi.nlm.nih.gov/pubmed/27233294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.231928
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