Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Sandwich-cultured hepatocytes (SCH) are metabolically competent and have proper localization of basolateral and canalicular transporters with functional bile networks. Therefore, this cellular model is a unique tool that can be used to estimate biliary excretion of compounds. SCH have been used wide...

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Publicado en:J Pharm Sci
Autores principales: YANG, KYUNGHEE, GUO, CEN, WOODHEAD, JEFFREY L, CLAIRE, ROBERT LST., WATKINS, PAUL B, SILER, SCOTT Q, HOWELL, BRETT A, BROUWER, KIM LR
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894499/
https://ncbi.nlm.nih.gov/pubmed/26869411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2015.11.008
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