Understanding hepatotoxicity – from patients to mice to computer

Por Watkins, Paul B
Publicado em 2012

Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling

Por Watkins, Paul B.
Publicado no CPT Pharmacometrics Syst Pharmacol (2018)

The DILI‐sim Initiative: Insights into Hepatotoxicity Mechanisms and Biomarker Interpretation

Por Watkins, Paul B.
Publicado no Clin Transl Sci (2019)

Drug-Induced Liver Injury: Advances in Mechanistic Understanding that will Inform Risk Management

Por Mosedale, Merrie, Watkins, Paul B.
Publicado no Clin Pharmacol Ther (2017)

The transformation in biomarker detection and management of drug-induced liver injury

Por Church, Rachel J., Watkins, Paul B.
Publicado no Liver Int (2017)

In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials

Por Church, Rachel J, Watkins, Paul B
Publicado no Exp Biol Med (Maywood) (2017)

Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here?

Por Urban, Thomas J., Goldstein, David B., Watkins, Paul B.
Publicado em 2012

Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury

Por Borlak, Jürgen, Chatterji, Bijon, Londhe, Kishor B, Watkins, Paul B
Publicado em 2013

Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

Por Wanwimolruk, Sompon, Paine, Mary F, Pusek, Susan N, Watkins, Paul B
Publicado em 2002

Identification of Identical Transcript Changes in Liver and Whole Blood during Acetaminophen Toxicity

Por Zhang, Liwen, Bushel, Pierre R., Chou, Jeff, Zhou, Tong, Watkins, Paul B.
Publicado em 2012

Effects of a prolonged standardized diet on normalizing the human metabolome(1)(2)(3)

Por Winnike, Jason H, Busby, Marjorie G, Watkins, Paul B, O'Connell, Thomas M
Publicado em 2009

Liver Safety Assessment in Special Populations (Hepatitis B, C, and Oncology Trials)

Por Kullak-Ublick, Gerd A., Merz, Michael, Griffel, Louis, Kaplowitz, Neil, Watkins, Paul B.
Publicado em 2014

Blood Gene Expression Profiling of an Early Acetaminophen Response

Por Bushel, Pierre R., Fannin, Rick D., Gerrish, Kevin, Watkins, Paul B., Paules, Richard S.
Publicado no Pharmacogenomics J (2016)

Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization

Por Fu, Dong, Cardona, Panli, Ho, Henry, Watkins, Paul B, Brouwer, Kim L R
Publicado no Toxicol Sci (2019)

Methodology to Assess Clinical Liver Safety Data

Por Merz, Michael, Lee, Kwan R., Kullak-Ublick, Gerd A., Brueckner, Andreas, Watkins, Paul B.
Publicado em 2014

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

Por Yang, Kyunghee, Woodhead, Jeffrey L, Watkins, Paul B, Howell, Brett A, Brouwer, Kim LR
Publicado no Clin Pharmacol Ther (2014)

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Por Holman, Natalie S., Mosedale, Merrie, Wolf, Kristina K., LeCluyse, Edward L., Watkins, Paul B.
Publicado no Toxicol Sci (2016)

Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine

Por Singhal, Rohit, Harrill, Alison H, Menguy-Vacheron, Francoise, Jayyosi, Zaid, Benzerdjeb, Hadj, Watkins, Paul B
Publicado em 2014

The Clinical Liver Safety Assessment Best Practices Workshop: Rationale, Goals, Accomplishments and the Future

Por Watkins, Paul B., Merz, Michael, Avigan, Mark I., Kaplowitz, Neil, Regev, Arie, Senior, John R.
Publicado em 2014

Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen

Por Fannin, Rick D., Gerrish, Kevin, Sieber, Stella O., Bushel, Pierre R., Watkins, Paul B., Paules, Richard S.
Publicado no Clin Pharmacol Ther (2016)