Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

Aims To evaluate the antimalarial agent quinine as a potential in vivo probe for hepatic cytochrome P450 (CYP) 3A4 activity. Methods Ten healthy adult volunteers received, by randomized crossover design, either a single oral dose of quinine sulphate (600 mg) alone, or quinine sulphate (600 mg) plus...

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Bibliographic Details
Main Authors: Wanwimolruk, Sompon, Paine, Mary F, Pusek, Susan N, Watkins, Paul B
Format: Artigo
Language:Inglês
Published: Blackwell Science Ltd 2002
Subjects:
Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874504/
https://ncbi.nlm.nih.gov/pubmed/12492613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01687.x
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